Research | Fundamental properties of ion channels and pores

The application of membrane proteins in biotechnology requires a sound understanding of their fundamental properties. We are interested in the stability, folding, assembly and functional properties of membrane proteins. These properties differ considerably from those of their soluble counterparts. In terms of functional properties, we are especially interested in the translocation of polymers through membrane pores such as α-hemolysin (DNA), Wza (oligosaccharides) and autotransporters (polypeptides).

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Research papers:

Rodriguez-Larrea, D. and Bayley, H. Multistep protein unfolding during nanopore translocation. Nature Nanotechnology 8, 288-295 (2013).DOI: 10.1038/nnano.2013.22

Stoddart, D., Ayub, M., Höfler, L., Raychaudhuri, P., Klingelhoefer, J.W., Maglia, G., Heron, A. and Bayley, H. Functional truncated membrane pores. Proc. Natl. Acad. Sci. USA 111, 2425-2430 (2014). www.pnas.org/cgi/doi/10.1073/pnas.1312976111

Review:
Bayley, H. Piercing insights, Nature 459, 651-652 (2009). DOI:10.1038/459651a