We are a chemical biology group which focuses on protein chemistry, molecular genetics and biophysics. Much of our work is centered on membrane proteins, in particular channels and pores. We are currently investigating both the fundamental properties of these proteins and their applications in biotechnology.
Several of our studies are collaborations with other laboratories in the UK, USA and Europe. There are currently 14 postdocs, 8 graduate students and a technician in the laboratory, from 12 different countries.
News from the Lab:
- We welcome postdoc Linna Zhou, PhD students Jianfei Feng and Yuja Qing to the group!
- We say goodbye to Visiting Prof. Lukas Tamm (Virginia, US) who was at Oxford on a 3 month sabbatical.
- Our new paper entitled ‘Functional truncated membrane pores’ has been published in PNAS. The paper describes the development of a new class of membrane proteins that stabilise lipid pores, as toroidal structures.
- Congratulations to Prof. Hagan Bayley, who has been named in the list of top 100 Leading UK Practising Scientists by the Science Council.
- Our new paper entitled ‘Single-molecule site-specific detection of protein phosphorylation with a nanopore’ has been published in Nature Biotechnology. Using the model protein thioredoxin, we demonstrate the detection of site-specific phosphorylations. Analysis of the ionic current amplitude and noise, as the protein unfolds and moves through the αHL pore, enables distinction between unphosphorylated, mono- and di-phosphorylated variants.
- Our new paper entitled ‘Detection of 3’-end RNA uridylation with a protein nanopore’ has been published in ACS Nano. Here, we demonstrate the detection of a post-transcriptional modification (uridylation) through studying the selective and transient binding of 3’-uridylated ssRNAs inside the beta-barrel of the αHL pore.
- Our new paper entitled ‘Construction and manipulation of functional 3D droplet networks’ has been published in ACS Nano. The paper describes the construction of 3D droplet networks with defined organisations by the manipulation of aqueous droplets containing encapsulated magnetic beads.
- Congratulations to DPhil student Alex Graham who won the Chemistry Department Lilly Prize for excellence in his first year of postgraduate study.
- The READNA consortium has been awarded with the ‘Stars of Europe’ prize by the French Ministry of Higher Education and Research. The award was presented to CNAG director Ivo Gut, during the French Horizon 2020 launch event on 16th December in Paris, France. Congratulations to everyone who was involved in the project. For more information, check out the following link: http://www.cnag.cat/article/readna-awarded-with-the-stars-of-europe-prize/?color=black.