We are a chemical biology group which focuses on protein chemistry, molecular genetics and biophysics. Much of our work is centered on membrane proteins, in particular channels and pores. We are currently investigating both the fundamental properties of these proteins and their applications in biotechnology.
Several of our studies are collaborations with other laboratories in the UK, USA and Europe. There are currently 14 postdocs, 8 graduate students and a technician in the laboratory, from 12 different countries.
News from the Lab:
- Our new paper entitled ‘Stochastic detection of Pim protein kinases reveals electrostatically enhanced association of a peptide substrate’ has been published in Proceedings of the National Academy of Sciences. The paper describes the stochastic detection of Pim protein kinases, where we observe electrostatically enhanced association rates for Pim and a consensus substrate, which suggests an additional element of control between cell-signalling pathways.
- Lots of new people joining us this month! We welcome postdocs Michael Booth, Sam Olof, Shaohua Ma, PhD student Sami Habash and Part II student Ivan Dimov to the lab.
- Our new paper entitled ‘Nanopore-based identification of individual nucleotides for direct RNA sequencing’ has been published in Nano Letters. The paper describes a label-free ribobase identification method to resolve ribonucleoside mono- and di-phosphates in protein pores containing cyclodextrin adapters. An exo-sequencing approach is envisioned in which a processive exoribonuclease presents sequentially cleaved ribonucleoside diphosphates to the nanopore.
- 2 new postdocs available within the Bayley group. For more information, check out the following link
- Postdoc James Cracknell, Rodolfo Gomez and visiting student Massimiliano Clamer are leaving the lab. We wish them all the best in their new posts!