We are a chemical biology group which focuses on protein chemistry, molecular genetics and biophysics. Much of our work is centered on membrane proteins, in particular channels and pores. We are currently investigating both the fundamental properties of these proteins and their applications in biotechnology.
Several of our studies are collaborations with other laboratories in the UK, USA and Europe. There are currently 14 postdocs, 8 graduate students and a technician in the laboratory, from 12 different countries.
News from the Lab:
- Our new paper entitled ‘Continuous observation of the stochastic motion of an individual small-molecule walker’ has been published in Nature Nanotechnology. The paper demonstrates the movement of a small-molecule walker along a five-foothold track that can be monitored continuously within the αHL protein nanoreactor. The work has also been highlighted in the University of Oxford Science blog.
- We welcome postdoc Jinghui Luo and students Nicole Galenkamp (visiting) and Kirsti Brisk (rotation) to the group!
- Our new collaborative paper entitled ‘Designing a hydrophobic barrier within biomimetic nanopores’ has been published in ACS Nano.
- Our new collaborative paper entitled ‘A droplet microfluidic system for sequential generation of lipid bilayers and transmembrane electrical recordings’ has been published in Lab on a Chip.
- Congratulations to Alex Graham who was one of the prize winners at the 2014 Pfizer second year graduate poster symposium.
- Our new paper entitled ‘Protein co-translocational unfolding depends on the direction of pulling’ has been published in Nature Communications. The paper describes how the unfolding kinetics of the model substrate thioredoxin, when pulled through the αHL pore are directly dependent on whether the process is initiated from the C or N terminus.
- We welcome postdoc Ankur Gupta, students Vanessa Restrepo-Schild (DPhil), Lu Cui (Part II) and Nuria Rodriguez-Vazquez (visiting) to the group!
- New postdoc position available. The project involves fundamental investigations of new types of molecules and their mechanisms of actions as nanotransporters. The position would be suitable for those with experience in single molecule chemistry including ion channel and pore technology, and skills in biochemical and molecular biological techniques. Application deadline 12/09/2014. More information on the post can be found here: Link
- We welcome postdocs Jianwei Li and Nobina Mukherjee to the group!