Our laboratory uses the techniques of protein chemistry, molecular genetics and biophysics. Much of our work is centered on membrane proteins, in particular channels and pores. We investigate both the fundamental properties of these proteins and their applications in biotechnology.
Several of our studies are collaborations with other laboratories in the UK, USA and Europe. There are currently 15 postdocs, 8 graduate students and a technician in the laboratory, from 10 different countries.
News from the Lab:
Postdocs David Rodriguez-Larrea, Leon Harrington and visiting student Nuria Rodriguez-Vazquez are leaving the lab. We wish them all the best in their new posts!
Congratulations to Jianfei Feng (Jeff) for successfully defending his transfer viva on 16th Jan 2015.
We welcome postdoc Sejeong Lee to the group.
- Our new paper entitled ‘Continuous observation of the stochastic motion of an individual small-molecule walker’ has been published in Nature Nanotechnology. The paper demonstrates the movement of a small-molecule walker along a five-foothold track that can be monitored continuously within the αHL protein nanoreactor. The work has also been highlighted on the University of Oxford Science blog.
- We welcome postdoc Jinghui Luo and students Nicole Galenkamp (visiting) and Kirsti Brisk (rotation) to the group!
- Our new collaborative paper entitled ‘Designing a hydrophobic barrier within biomimetic nanopores’ has been published in ACS Nano.
- Our new collaborative paper entitled ‘A droplet microfluidic system for sequential generation of lipid bilayers and transmembrane electrical recordings’ has been published in Lab on a Chip.
- Congratulations to Alex Graham who was one of the prize winners at the 2014 Pfizer second year graduate poster symposium.
- Our new paper entitled ‘Protein co-translocational unfolding depends on the direction of pulling’ has been published in Nature Communications. The paper describes how the unfolding kinetics of the model substrate thioredoxin, when pulled through the αHL pore are directly dependent on whether the process is initiated from the C or N terminus.
- We welcome postdoc Ankur Gupta, students Vanessa Restrepo-Schild (DPhil), Lu Cui (Part II) and Nuria Rodriguez-Vazquez (visiting) to the group!