Welcome to the Hagan Bayley Lab in the Chemical Research Laboratory of Chemistry Department at the University of Oxford.
We are a chemical biology group which focuses on protein chemistry, molecular genetics and biophysics. Much of our work is centered on membrane proteins, in particular channels and pores. We are currently investigating both the fundamental properties of these proteins and their applications in biotechnology.
News from the Lab:
- Our new paper entitled ‘Single-molecule detection of 5-hydroxymethylcytosine in DNA through chemical modification and nanopore analysis’ has been published in Angewandte Chemie IE. The paper describes selective thiol substitution of 5hmC (giving SMC) in a single-step, bisulfite-mediated reaction that allows the incorporation of a peptide, The modified 5hmC bases can then be readily distinguished at the single-molecule level using protein nanopore analysis.
- Our new paper entitled ‘A tissue-like printed material’ published in Science and featured on the journal cover page has received international coverage including articles in Nature News, The Economist, New Scientist, NBC News, RSC Chemistry World, CBS News, National Geographic and Engadget. The paper describes the production of three-dimensionally patterned, interconnected networks of lipid-bounded structures functionalized with transmembrane proteins, which allow electrical communication along specific pathways. The networks can also be programmed by osmolarity gradients to fold into otherwise unattainable designed structures. Printed droplet networks might be interfaced with tissues, used as tissue engineering substrates, or developed as mimics of living tissue.
- Congratulations to Dr. Gabriel Villar for successfully defending his thesis on 7th March 2013.
- Our new paper entitled ‘Multi-step protein unfolding during nanpore translocation’ has been published in Nature Nanotechnology. The paper investigated how folded proteins use narrow transmembrane pores to move between compartments. We propose a 4-step mechanism associated to the unfolding of thioredoxin model protein.
- PhD students Pinky Raychaudhuri and Gabriel Villar are leaving the lab. We wish them all the best in their new posts!
- Congratulations to Dr. Shiksha Mantri for successfully defending her thesis on 23rd January 2013.
- Postdoc positions are now available within our group. More details can be found here. Deadline- 15/02/2013
- The Bayley group is now on Twitter! Follow us: @bayley_lab
- We welcome postdoc Rodolfo Gomez and PhD visiting student Christian Rosen to the lab!
- Postdoc Tanuj Sapra and Lai-Sheung Choi are leaving the lab. We wish them all the best in their new posts!
- Our new paper titled ‘Lipid-coated hydrogel shapes as components of electrical circuits and mechanical devices’ has been published in Scientific Reports. The paper demonstrates how hydrogel shapes, coated with lipid monolayers, can be used as building blocks for functional networks, yielding scalable electrical circuits and mechanical devices.
- Congratulations to Dr. Pinky Raychaudhuri for successfully defending her thesis on 9th Nov 2012.
- We welcome postdocs Mahendran Radhakrishnan, Daisuke Noshiro, Krishna Bhabak and PhD visiting student Aurore Delachat to the lab!
- Our work on the stochastic detection of neurotransmitters has been highlighted in Nanomedicine News and Views.
- Postdoc Holger Gerlach is leaving the Bayley lab. We wish him all the best in his new post!
- Our new paper entitled ‘Individual RNA base recognition in immobilized oligonucleotides using a protein nanopore’ has been published in Nano Letters. The paper describes the discrimination between RNA bases immobilized in the αHL nanopore.