Our laboratory uses the techniques of protein chemistry, molecular genetics and biophysics. Much of our work is centered on membrane proteins, in particular channels and pores. We investigate both the fundamental properties of these proteins and their applications in biotechnology.
Several of our studies are collaborations with other laboratories in the UK, USA and Europe. There are currently 21 postdocs, 8 graduate students and a technician in the laboratory, from 10 different countries.
News from the Lab:
Our new paper ‘A semisynthetic protein nanoreactor for single molecule-chemistry’ has been published in PNAS. The paper describes the development of semisynthetic pores containing a terminal alkyne, used as a nanoreactor to study Cu(I)-catalysed azide-alkyne cycloadditions.
In memory of Stephen Bengt Cheley. Steve was in our group from 1988 to 2005 and from 2007 to 2012, more than 20 years. He contributed to over 50 papers, and was a colleague and mentor to many past and current members of the group PDF
Our new collaborative paper ‘The role of lipids in mechanosensation’ has been published in Nature Structural Molecular Biology.